Naive 20-something Josh Greenberg is in search of love. Things aren't exactly in his favor to find his ideal mate -- for he has a bad job and apartment and is afraid to approach women. But his best-friend/confidant Mike -- his polar opposite -- is a cool, confident bro with an expense account. Mike is also the proverbial devil on his buddy's shoulder, pushing him to engage in activities like sex and drugs. Also in Josh's life is his sister Liz, a corporate lawyer who wants him to get his act together. When Josh does finally find love, he tackles his toughest challenge to date: a serious, long-term relationship and all that comes with it, including anniversaries, merging friend groups, and learning to live their lives as a team.
Life can be hectic for a newly single father and successful stand-up comedian -- just ask Louie, a fictionalized version of comic Louis C.K., who portrays the character. From his first meeting of the PTA to dating again and navigating the big city with two children, the comic shares pieces of his day with an appreciative audience during his stand-up gigs. The series features appearances by a number of stand-up comedians appearing in the show as fictionalized versions of themselves. In addition to starring in the show, Louis C.K. also created it.
Several friends own Paddy's Pub, a neighborhood bar in Philadelphia, and try to find their way in the world of work and relationships. But often, they can't get out of their own way, leading to uncomfortable situations, which usually worsen before improving. The gang includes twin siblings Dennis and Sweet Dee Reynolds, along with their longtime friends, Charlie Kelly and Ronald "Mac" McDonald. Charlie lives with Frank, Dennis and Sweet Dee's father, who has left his cheating, money-grabbing wife in an attempt to redeem himself after a history of doing business with sketchy people.
Sam Fox is an actress, who is also a single mother raising three daughters -- teenager Max, eccentric middle child Frankie, and spicy youngest daughter Duke -- in Los Angeles. She also helps to care for her mother, Phil, who lives across the street. In addition to looking after her family, Sam tries to earn a living in the difficult acting industry while having time to have fun with friends and, occasionally, take time for herself to squeeze in some private time. In addition to starring as Sam, Emmy winner Pamela Adlon is a co-creator of the comedy series, along with Louis C.K.
Some friends who are all avid fantasy football fans try to balance their time between the league and their real lives. It becomes a challenge, though, when the good-natured competition gives way to a win-at-all-costs mentality, which begins to spill over into their relationships and even the workplace. It's a cutthroat competition to win the league -- and the bragging rights that come with the feat. The sitcom features a plethora of cameos by real-life NFL players, who play themselves on the series.
After going through a rough breakup, awkward and upbeat Jess (Zooey Deschanel) moves in with three single guys. Intelligent and witty Nick is an underachiever who took the bartender off-ramp on his road to success. Schmidt obsesses over his social standing and looks at Jess as a personal project. Winston is a competitive former athlete who, after realizing he will never become a pro, moves into the loft. Together with Jess' best friend, Cece, they bond to form an unlikely, and dysfunctional, family.