Naive 20-something Josh Greenberg is in search of love. Things aren't exactly in his favor to find his ideal mate -- for he has a bad job and apartment and is afraid to approach women. But his best-friend/confidant Mike -- his polar opposite -- is a cool, confident bro with an expense account. Mike is also the proverbial devil on his buddy's shoulder, pushing him to engage in activities like sex and drugs. Also in Josh's life is his sister Liz, a corporate lawyer who wants him to get his act together. When Josh does finally find love, he tackles his toughest challenge to date: a serious, long-term relationship and all that comes with it, including anniversaries, merging friend groups, and learning to live their lives as a team.
Several friends own Paddy's Pub, a neighborhood bar in Philadelphia, and try to find their way in the world of work and relationships. But often, they can't get out of their own way, leading to uncomfortable situations, which usually worsen before improving. The gang includes twin siblings Dennis and Sweet Dee Reynolds, along with their longtime friends, Charlie Kelly and Ronald "Mac" McDonald. Charlie lives with Frank, Dennis and Sweet Dee's father, who has left his cheating, money-grabbing wife in an attempt to redeem himself after a history of doing business with sketchy people.
Ted has fallen in love. It all started when his best friend, Marshall, drops the bombshell that he plans to propose to longtime girlfriend Lily, a kindergarten teacher. Suddenly, Ted realizes that he had better get a move on if he hopes to find true love. Helping him in the quest is Barney, a friend with endless -- often outrageous -- opinions, a penchant for suits and a foolproof way to meet women. When Ted meets Robin, he is sure it's love at first sight, but the affair fizzles into friendship. Voice-over by Bob Saget ("Full House") tells the story through flashbacks.
After going through a rough breakup, awkward and upbeat Jess (Zooey Deschanel) moves in with three single guys. Intelligent and witty Nick is an underachiever who took the bartender off-ramp on his road to success. Schmidt obsesses over his social standing and looks at Jess as a personal project. Winston is a competitive former athlete who, after realizing he will never become a pro, moves into the loft. Together with Jess' best friend, Cece, they bond to form an unlikely, and dysfunctional, family.
Early '90s band The Heathens lived up to that name offstage as well as on it, partying hard and using drugs. Led by Johnny Rock, the group was on the brink of fame with the release of its first album. Then, the band broke up -- on the day of the album's release -- because lead guitarist Flash discovered Johnny in bed with his wife. "Sex&Drugs&Rock&Roll" picks up the story a quarter-century later when the drugs Johnny is using are of the prescription variety rather than cocaine and marijuana. He's out of work, money and options -- until young singer Gigi, who has a burning desire for fame, shows up with a stack of cash and an offer to get the band out of obscurity and back into the studio. The only catch is that she wants to be the lead singer, and Johnny must stay out of the spotlight as a songwriter.
Sam Fox is an actress, who is also a single mother raising three daughters -- teenager Max, eccentric middle child Frankie, and spicy youngest daughter Duke -- in Los Angeles. She also helps to care for her mother, Phil, who lives across the street. In addition to looking after her family, Sam tries to earn a living in the difficult acting industry while having time to have fun with friends and, occasionally, take time for herself to squeeze in some private time. In addition to starring as Sam, Emmy winner Pamela Adlon is a co-creator of the comedy series, along with Louis C.K.