"You're the Worst" isn't a typical romantic comedy. Narcissist Jimmy Shive-Overly thinks all relationships are doomed from the start, while stubborn cynic Gretchen Cutler is certain that amorous bonds aren't her thing. When the two meet at a wedding, though, there's a sea change: They go home together and find they're beginning to fall for each other. Jimmy and Gretchen navigate fear, heartbreak, ardor and other feelings, and their situation seems to establish that nontraditionalists sometimes make great partners -- but not forever. They eventually break up and become involved with other people, leading them to struggle to move on while being pulled back toward each other.
Several friends own Paddy's Pub, a neighborhood bar in Philadelphia, and try to find their way in the world of work and relationships. But often, they can't get out of their own way, leading to uncomfortable situations, which usually worsen before improving. The gang includes twin siblings Dennis and Sweet Dee Reynolds, along with their longtime friends, Charlie Kelly and Ronald "Mac" McDonald. Charlie lives with Frank, Dennis and Sweet Dee's father, who has left his cheating, money-grabbing wife in an attempt to redeem himself after a history of doing business with sketchy people.
The close-knit, Chicago-based O'Neals seem to be the perfect Catholic family, but when surprising truths come to light, some lives take an unexpected turn. Eileen, Pat, Kenny, Jimmy, Shannon and Jodi decide to let the honesty ring in a new, less tidy chapter of their story, where they all drop their carefully honed facades and discover the unexpected freedom that accompanies just acting real. Instead of being torn apart, the O'Neals find that their newfound way of life actually brings them closer together.
Sam Fox is an actress, who is also a single mother raising three daughters -- teenager Max, eccentric middle child Frankie, and spicy youngest daughter Duke -- in Los Angeles. She also helps to care for her mother, Phil, who lives across the street. In addition to looking after her family, Sam tries to earn a living in the difficult acting industry while having time to have fun with friends and, occasionally, take time for herself to squeeze in some private time. In addition to starring as Sam, Emmy winner Pamela Adlon is a co-creator of the comedy series, along with Louis C.K.
After Abby McCarthy, author of self-help books and guru to people with family issues, states that she and her husband have separated, her career screeches to a halt. The revelation puts America's once-favorite girlfriend in free fall. Acclimating to being single in her 40s, she turns to friends for advice, including entrepreneur Phoebe, who has an odd relationship with her ex. For the divorce, Abby hires Delia, an associate of her friend, Lyla. The "Girlfriends' Guide" book series inspired the dramedy -- Bravo's first original scripted series.
Mike, a Chicago police officer, meets fourth-grade teacher Molly one day when he speaks at an Overeaters Anonymous meeting and they fall in love, thanks in part to their mutual love of pie and the desire to resist it. Both face challenges in their quest to lose weight -- Molly from her slender sister and mother and Mike at the diner where he frequently eats. But having found each other, they will support each other as they try to achieve their goals, be it weight loss or Molly's decision to quit teaching and pursue her dream as a writer.
After going through a rough breakup, awkward and upbeat Jess (Zooey Deschanel) moves in with three single guys. Intelligent and witty Nick is an underachiever who took the bartender off-ramp on his road to success. Schmidt obsesses over his social standing and looks at Jess as a personal project. Winston is a competitive former athlete who, after realizing he will never become a pro, moves into the loft. Together with Jess' best friend, Cece, they bond to form an unlikely, and dysfunctional, family.
Life can be hectic for a newly single father and successful stand-up comedian -- just ask Louie, a fictionalized version of comic Louis C.K., who portrays the character. From his first meeting of the PTA to dating again and navigating the big city with two children, the comic shares pieces of his day with an appreciative audience during his stand-up gigs. The series features appearances by a number of stand-up comedians appearing in the show as fictionalized versions of themselves. In addition to starring in the show, Louis C.K. also created it.