After Abby McCarthy, author of self-help books and guru to people with family issues, states that she and her husband have separated, her career screeches to a halt. The revelation puts America's once-favorite girlfriend in free fall. Acclimating to being single in her 40s, she turns to friends for advice, including entrepreneur Phoebe, who has an odd relationship with her ex. For the divorce, Abby hires Delia, an associate of her friend, Lyla. The "Girlfriends' Guide" book series inspired the dramedy -- Bravo's first original scripted series.