From their homes, Desus Nice and The Kid Mero welcome immunologist Dr. Anthony Fauci.

Desus Nice and The Kid Mero welcome Rep. Maxine Waters (D-Calif.)

Desus Nice and The Kid Mero welcome actor Penn Badgley.

Desus Nice and The Kid Mero welcome Rep. Alexandria Ocasio-Cortez (D-N.Y.).

Desus Nice and The Kid Mero have an extended conversation with TV talk show host David Letterman.

Desus Nice and The Kid Mero welcome comic John Mulaney.

Desus Nice and The Kid Mero welcome TV show host Seth Meyers.

Desus Nice and The Kid Mero welcome rapper Wale.

Desus Nice and The Kid Mero welcome actor Nick Kroll.

Desus Nice and The Kid Mero welcome rapper Missy Elliott.

Desus Nice and The Kid Mero welcome rapper Killer Mike.

Desus Nice and The Kid Mero welcome actor Lakeith Stanfield.

Desus Nice and The Kid Mero welcome TV talk show host David Letterman.

Desus Nice and The Kid Mero welcome actor Chadwick Boseman and State Sen. Elizabeth Warren (D- Mass.)

Desus and Mero welcome author Shea Serrano.

Desus and Mero welcome comedian Hasan Minhaj.

Desus and Mero welcome journalist Chris Hayes.

Desus and Mero welcome actor Kenan Thompson.

Desus and Mero welcome actress Anna Kendrick.

Desus and Mero welcome illustrious guest Sen. Bernie Sanders (I-Vt.).

Desus and Mero welcome illustrious guest comedian Bill Burr.

The comic, actress, social media sensation, producer and author of "How to Be a Bawse: A Guide to Conquering Life," Lilly Singh brings her unique perspective to late night as she hosts celebrity interviews, talks current events, performs musical and sketch comedy, plays games, and more. A self-proclaimed unicorn, the multi-faceted star's debut in the late-night landscape is especially noteworthy as she's a Canadian woman of Indian descent, combining a fresh take on the day's events, pop culture, diversity and life.

Actress Busy Philipps hosts this late-night talk show featuring comedic commentary, celebrity interviews, topical segments, and fun games. The show goes behind Busy's most popular Instagram stories and showcases her most candid moments in front of a live studio audience. With the help of her crew of writers, Busy hits viewers with buzzworthy highlights from the week. Unfiltered, in-the-know and always entertaining, Busy presents her unique and hilarious point of view on literally everything.

An extension of Bravo's "Watch What Happens" reunion specials and the original live online shows, this interactive series -- live on the East Coast -- is hosted by former Bravo programming executive Andy Cohen, who welcomes guests from some of the cable network's most popular series, as well as other entertainment stars, to chat about pop culture and celebrities in the news. In 2017, the show took on a new title -- "Watch What Happens Live With Andy Cohen" -- as part of an overhaul that included a remodeled studio offering a designated performance space for musical guests, a staple of most late-night shows.

With his signature monologue and sharp newsy segments like "A Closer Look," Seth Meyers hilariously breaks down the day's biggest stories and takes the current political circus head-on. He then welcomes Hollywood's most beloved A-list guests, as well as people not seen anywhere else in late night, like political figures and other interesting newsmakers. With fan-favorite comedy segments that become viral sensations, and the talented 8G band at his side, Seth consistently brings home the last laugh.

Emmy-winning funnyman Jimmy Kimmel serves up comedy bits and welcomes guests that include other comics, celebrities, athletes and musicians, as well as everyday people with unusual or compelling personal stories. Kimmel's family and friends take part in the festivities, including his Cousin Sal, Uncle Frank (until his death in 2011) and childhood friend Cleto Escobedo III, who leads the show's house band. Recurring segments include the FCC-pleasing This Week in Unnecessary Censorship in which they take TV clips and "bleep and blur things whether they need it or not," as Kimmel describes it. But it's too bad they consistently run out of time for Matt Damon's segment.

Heeeere's Conan! The former longtime host of "Late Night" and abbreviated presenter of "The Tonight Show" moves his talk show act to the cable arena, where he becomes the staple of TBS' late-night talk show lineup. Making the transition to basic cable with Conan is his on-again, off-again sidekick/announcer, Andy Richter. Said O'Brien in his typical dry tone, "In three months I've gone from network television to Twitter to performing live in theaters, and now I'm headed to basic cable. My plan is working perfectly."

Hailing from Rockefeller Center in the heart of New York City, Jimmy has made it his mission to make sure viewers end the day with a smile. Each weeknight, he hosts A-list guests, from movie stars to athletes, comedians, public figures and everyone in between. He also delivers a signature nightly monologue, performs in topical comedy sketches, plays fan-favorite games, and presents recurring segments like Thank You Notes. Today's popular musical guests also stop by to perform alongside house band The Roots.

Improv actor and comic Stephen Colbert flexes the hosting muscles he honed over nearly 1,500 episodes of the popular and critically celebrated "The Colbert Report" at the helm of this long-running late-night talk show. Following the genre's classic formula, each show kicks off with a monologue and a look at recent headlines, and features sketch comedy, celebrity interviews and musical performances. Joining Colbert is his bandleader, Julliard-trained Jon Batiste, and house band Stay Human. The show is filmed in New York's famed Ed Sullivan Theater, the longtime home of "The Late Show."

Veteran writer and comedian David Steinberg sits down with comics and other entertainers for one-on-one interviews in this series that delves into the stars' lives and careers. Steinberg's guests -- a list that includes such luminaries as Chris Rock, Jerry Seinfeld, Mel Brooks, Don Rickles and Jonathan Winters -- share career-defining moments, personal struggles and the idols who inspired them. These intimate interviews give viewers a glimpse into what makes legendary comedians who they are, both personally and professionally. The hard-working Steinberg not only hosts the show but also serves as an executive producer and directs each episode.