Mike, a Chicago police officer, meets fourth-grade teacher Molly one day when he speaks at an Overeaters Anonymous meeting and they fall in love, thanks in part to their mutual love of pie and the desire to resist it. Both face challenges in their quest to lose weight -- Molly from her slender sister and mother and Mike at the diner where he frequently eats. But having found each other, they will support each other as they try to achieve their goals, be it weight loss or Molly's decision to quit teaching and pursue her dream as a writer.
After going through a rough breakup, awkward and upbeat Jess (Zooey Deschanel) moves in with three single guys. Intelligent and witty Nick is an underachiever who took the bartender off-ramp on his road to success. Schmidt obsesses over his social standing and looks at Jess as a personal project. Winston is a competitive former athlete who, after realizing he will never become a pro, moves into the loft. Together with Jess' best friend, Cece, they bond to form an unlikely, and dysfunctional, family.
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?
Single mom Christy has her hands full with two children, Violet and Roscoe, and maintaining newfound sobriety, when her passive-aggressive, recovering-alcoholic mother re-enters the picture, brimming with criticisms about Christy's life. As the daughter works to be the best mother she can and to overcome mistakes she made, she must also navigate dysfunctional relationships with romantic interests, and with her irresponsible ex-husband, Baxter. Despite the uphill battle, Christy tries to remain positive and stay on a path to help her reach her goals.
Ted has fallen in love. It all started when his best friend, Marshall, drops the bombshell that he plans to propose to longtime girlfriend Lily, a kindergarten teacher. Suddenly, Ted realizes that he had better get a move on if he hopes to find true love. Helping him in the quest is Barney, a friend with endless -- often outrageous -- opinions, a penchant for suits and a foolproof way to meet women. When Ted meets Robin, he is sure it's love at first sight, but the affair fizzles into friendship. Voice-over by Bob Saget ("Full House") tells the story through flashbacks.
The different phases of male-female relationships are examined as seen through the eyes of young couple Adam and Jennifer. Their friends include longtime-married pair Jeff and Audrey, and a womanizing singleton named Russell. As Adam and Jennifer find out, the often-confusing stages of a relationship can seem like a ride on a roller coaster: Folks can describe it to you, but you have to take the trip for yourself to know what it's like.
Detective Jake Peralta, a talented and carefree cop with the best arrest record, has never had to follow the rules too closely or work very hard. That changes when Ray Holt, a man with a lot to prove, becomes the new commanding officer of Brooklyn's 99th precinct. As Holt reminds Peralta to respect the badge, an extremely competitive colleague -- Detective Amy Santiago -- starts to close in on the hotshot cop's arrest record. Other members of the precinct include Sgt. Terry Jeffords, a devoted family man, Detective Charles Boyle, a hard worker who idolizes Jake, and Rosa Diaz, a sexy-yet-intimidating detective. Civilian office manager Gina Linetti is tasked with cleaning up everyone's mess, while somehow getting involved in everyone's business.
Mike Baxter is the quintessential man's man. Unfortunately, there isn't a lot of room for that at home where he lives with his three daughters and wife, Vanessa. The only other male in the house is his oldest daughter's young son, Boyd. Now, after being a stay-at-home mom for years, Vanessa goes back to work, forcing Mike to take on more parental responsibility than ever before. But his daughters aren't prepared for their old-fashioned, hotheaded patriarch to take over the house. When not at home, Mike is surrounded by men at his job at sporting-goods retailer Outdoor Man, which sells items like guns, jerky and camouflage recliners.
Surprise! You're a father! Bartender Ben comes home one day and finds that an ex-girlfriend has left a baby girl on his doorstep. The addition to Ben's family -- or having a family -- turns his life upside down. As a New York bachelor in his 20s, being a single dad doesn't fit his lifestyle. After much deliberation, Ben decides to raise the baby with help from his buddy Tucker, brother Danny, and hovering mom Bonnie. Also law student Riley -- once chubby, now slim -- wants Ben to take notice of her, but it's Danny who does.
Told from the perspective of an unseen documentary filmmaker, the series offers an honest, often-hilarious perspective of family life. Parents Phil and Claire yearn for an honest, open relationship with their three kids. But a daughter who is trying to grow up too fast, another who is too smart for her own good, and a rambunctious young son make it challenging. Claire's dad, Jay, and his Latina wife, Gloria, are raising two sons together, but people sometimes believe Jay to be Gloria's father. Jay's gay son, Mitchell, and his partner, Cameron, have adopted a little Asian girl, completing one big -- straight, gay, multicultural, traditional -- happy family.