For decades, ex-government agent Raymond "Red" Reddington has been one of the globe's most wanted fugitives. But then he agreed to work with the FBI to catch his "blacklist" of mobsters, spies and international terrorists -- on the condition that he must work with profiler Elizabeth Keen. Red's true intentions -- choosing Liz, a woman with whom he seemingly has no connection -- are unclear. Does Liz have secrets of her own? Red promises to teach Liz to think like a criminal "to see the bigger picture," whether she wants to or not.
A man from the post-apocalyptic future, Cole uses a dangerous, untested method of time travel to get from 2043 to the present day. He is on a mission to locate and rid the world of the source of the plague that will eventually annihilate the human race. Assisting him is Dr. Cassandra Railly, a virologist who must decide whether to do harm in order to save the world -- regardless of the fact that she has taken the Hippocratic oath. The sci-fi series is based on Terry Gilliam's 1995 film, which starred Bruce Willis as Cole.
In the not-too-distant future, Los Angeles has been invaded and occupied by outside forces, causing a rift between the city's residents; some have collaborated with the occupation, while others are rebelling and suffering the consequences that come with that choice. Former FBI agent Will Bowman and his wife, Katie, must consider their familial obligations when making their decision because they were separated from their son, Bram, during the invasion. Proxy Snyder, a cunning and powerful leader within the occupational government, offers Will the opportunity to get Bram back if he works with the invading faction. Will's decision doesn't sit well with Katie, but the couple risk their lives -- and their relationship -- to protect their family.
At 11, Barry Allen's life changed completely when his mother died in a freak accident and his innocent father was convicted of her murder. Now a crime-scene investigator, his dedication to learn the truth about his mother's death drives him to follow up on every new scientific advancement and urban legend. When his latest obsession -- a particle accelerator heralded as a world-changing invention -- causes an explosion, it creates a freak storm and Barry is struck by lightning. He awakes from a coma nine months later with the power of superspeed. When he learns that others who have gained powers use them for evil, he dedicates himself to protecting the innocent, while still trying to solve the older mystery.
Phil Coulson (Clark Gregg, reprising his role from "The Avengers" and "Iron Man" ) heads an elite team of fellow agents with the worldwide law-enforcement organization known as SHIELD (Strategic Homeland Intervention Enforcement and Logistics Division), as they investigate strange occurrences around the globe. Its members -- each of whom brings a specialty to the group -- work with Coulson to protect those who cannot protect themselves from extraordinary and inconceivable threats, including a formidable group known as Hydra.