Ted has fallen in love. It all started when his best friend, Marshall, drops the bombshell that he plans to propose to longtime girlfriend Lily, a kindergarten teacher. Suddenly, Ted realizes that he had better get a move on if he hopes to find true love. Helping him in the quest is Barney, a friend with endless -- often outrageous -- opinions, a penchant for suits and a foolproof way to meet women. When Ted meets Robin, he is sure it's love at first sight, but the affair fizzles into friendship. Voice-over by Bob Saget ("Full House") tells the story through flashbacks.
Chiropractor and single father Alan Harper lives in a beachfront house with divorced Internet billionaire Walden Schmidt, who bought the house following the untimely death of Alan's brother, Charlie. As they acclimate to their living arrangement, the tightly wound Alan finds himself taking on a mentor role with Walden, whose lifelong dependence on being taken care of has left him a bit naive. Despite his unsuccessful romantic history, Alan also tries to help Walden overcome his limited experiences with dating. Berta, a sharp-tongued, unapologetic housekeeper, is also featured in the series.
Three young men and three young women - of the BFF kind - live in the same apartment complex and face life and love in New York. They're not above sticking their noses into one another's businesses and swapping romantic partners, which always leads to the kind of hilarity average people will never experience - especially during breakups.
Doug Heffernan puts in a long day's work delivering parcels and comes home each night to his loving wife, Carrie; unfortunately, he also comes home to his wacko father-in-law, Arthur.
Street-wise Max (Kat Dennings) doesn't expect much from the new waitress at her night job, a rich girl who has reluctantly joined the food service industry after a string of bad luck. But to her surprise, Caroline (Beth Behrs) is a woman of substance and just may be her ticket to success. The two strike up an unlikely friendship after Caroline discovers that Max can bake a mean cupcake, and the women decide if they can just wrangle up the start-up cash, they may have found their big break. Their co-workers at the diner are boss Han Lee, cook Oleg and cashier Earl.
When her sister ends up in prison and her brother-in-law disappears, local politician Mel Burke steps in to take responsibility for her teenage niece Lennox and adolescent nephew Ryder. Realizing quickly she's in over her head, Mel welcomes help in the unlikely form of Joe Longo -- formerly a commodities trader -- who moves in and becomes the family's "manny" ... that is until Joe goes from being Mel's employee to becoming her husband when they marry.
Michael Kyle is a man on a tragically funny quest for the perfect "traditional" family while his wife searches for her own path in life.
Mike, a Chicago police officer, meets fourth-grade teacher Molly one day when he speaks at an Overeaters Anonymous meeting and they fall in love, thanks in part to their mutual love of pie and the desire to resist it. Both face challenges in their quest to lose weight -- Molly from her slender sister and mother and Mike at the diner where he frequently eats. But having found each other, they will support each other as they try to achieve their goals, be it weight loss or Molly's decision to quit teaching and pursue her dream as a writer.
Mindy Lahiri is a successful, skilled doctor, but when she leaves the office, all bets are off. She aspires to become a more well-rounded woman, someone who is punctual, frugal and well-read instead of someone who is obsessed with romantic comedies and likely to give an inappropriate toast at a wedding. Despite stumbles, Mindy remains determined to get her personal and romantic life on track -- before her friends and colleagues are forced to stage an intervention -- and find her perfect happy ending.
Melinda Gordon is a young woman who can communicate with the earthbound spirits of people who have died -- and who seek her help. She uses it to relay significant messages and important information to the living, but sometimes the messages she receives are intense and confusing. As a result the spirits' survivors often question her ability. But when she helps both the souls who contact her and those who are still alive, she knows that her talent is more asset than liability.