Chiropractor and single father Alan Harper lives in a beachfront house with divorced Internet billionaire Walden Schmidt, who bought the house following the untimely death of Alan's brother, Charlie. As they acclimate to their living arrangement, the tightly wound Alan finds himself taking on a mentor role with Walden, whose lifelong dependence on being taken care of has left him a bit naive. Despite his unsuccessful romantic history, Alan also tries to help Walden overcome his limited experiences with dating. Berta, a sharp-tongued, unapologetic housekeeper, is also featured in the series.
Surprise! You're a father! Bartender Ben comes home one day and finds that an ex-girlfriend has left a baby girl on his doorstep. The addition to Ben's family -- or having a family -- turns his life upside down. As a New York bachelor in his 20s, being a single dad doesn't fit his lifestyle. After much deliberation, Ben decides to raise the baby with help from his buddy Tucker, brother Danny, and hovering mom Bonnie. Also law student Riley -- once chubby, now slim -- wants Ben to take notice of her, but it's Danny who does.
Mike, a Chicago police officer, meets fourth-grade teacher Molly one day when he speaks at an Overeaters Anonymous meeting and they fall in love, thanks in part to their mutual love of pie and the desire to resist it. Both face challenges in their quest to lose weight -- Molly from her slender sister and mother and Mike at the diner where he frequently eats. But having found each other, they will support each other as they try to achieve their goals, be it weight loss or Molly's decision to quit teaching and pursue her dream as a writer.
When her sister ends up in prison and her brother-in-law disappears, local politician Mel Burke steps in to take responsibility for her teenage niece Lennox and adolescent nephew Ryder. Realizing quickly she's in over her head, Mel welcomes help in the unlikely form of Joe Longo -- formerly a commodities trader -- who moves in and becomes the family's "manny" ... that is until Joe goes from being Mel's employee to becoming her husband when they marry.
Life can be hectic for a newly single father and successful stand-up comedian -- just ask Louie, a fictionalized version of comic Louis C.K., who portrays the character. From his first meeting of the PTA to dating again and navigating the big city with two children, the comic shares pieces of his day with an appreciative audience during his stand-up gigs. The series features appearances by a number of stand-up comedians appearing in the show as fictionalized versions of themselves. In addition to starring in the show, Louis C.K. also created it.
"You're the Worst" isn't a typical romantic comedy. Narcissist Jimmy Shive-Overly thinks all relationships are doomed from the start, while stubborn cynic Gretchen Cutler is certain that amorous bonds aren't her thing. When the two meet at a wedding, though, there's a sea change: They go home together and find they're beginning to fall for each other. Jimmy and Gretchen navigate fear, heartbreak, ardor and other feelings, and their situation seems to establish that nontraditionalists sometimes make great partners -- but not forever. They eventually break up and become involved with other people, leading them to struggle to move on while being pulled back toward each other.
Several friends own Paddy's Pub, a neighborhood bar in Philadelphia, and try to find their way in the world of work and relationships. But often, they can't get out of their own way, leading to uncomfortable situations, which usually worsen before improving. The gang includes twin siblings Dennis and Sweet Dee Reynolds, along with their longtime friends, Charlie Kelly and Ronald "Mac" McDonald. Charlie lives with Frank, Dennis and Sweet Dee's father, who has left his cheating, money-grabbing wife in an attempt to redeem himself after a history of doing business with sketchy people.