Cillas' food addiction is getting in the way of his ability to be there for his fiancée, Jessica, and her three daughters.

Liz is completely bed bound with severe lymphedema that makes it impossible to walk; isolated, with no friends, she battles depression, and lives with her mom, who is too ill to take care of her.

Benji hopes to be able to support both himself and his brother, who is unable to work on their life-or-death weight loss journey.

At over 700 pounds, Brianne undertakes a weight-loss journey to save her own life; she faces an unexpected challenge to her fragile progress when her husband suffers a heart attack on a birthday she will never forget.

26-year-old Sean weighs over 700-lbs with a massive growth protruding from his side and skin so stretched it is tearing apart.

Chuck weighs almost 700lbs and it has hindered every aspect of his life; he's had to downsize his business and his wife feels like a single-parent.

Melissa struggles to get to her ideal weight.

Melissa begins her seven-year weight-loss journey.