As fog begins to cover Seattle, the doctors must navigate through personal complications; Meredith and Alex attempt to save Gus; Levi talks some sense into a struggling Nico.

Alex tries desperately to save his patient while he waits for a severely agoraphobic blood donor to arrive from London; Jo reveals to Meredith why she's been so down.

Maggie treats someone from Station 19; Jo learns a hard lesson; when working with a family that is seeking asylum, Meredith makes a call that could jeopardize her career.

Meredith debates how to handle an unexpected situation in her personal life; Richard has an untimely reunion with an old friend; Jo has a hard time at work; Owen tries therapy.

Amelia and Link travel to New York to operate on a patient who has a severe spinal deformity, but they're in for more than they bargained for when Nancy Shepherd invites them to dinner at her home.

Practically raised at Seattle's Station 19, Andy Herrera is a confident firefighter who is also the daughter of Pruitt Herrera, the formidable head of the firehouse. Capt. Pruitt was Andy's primary inspiration to become a firefighter and is a mentor to both her and Jack Gibson, the lieutenant at the station. Jack is as fearless as Andy is by-the-books, but when the two are together, sparks fly and opposites attract. The two are joined by Maya Bishop, Dean Miller, Travis Montgomery, Victoria Hughes, and the station's newest addition, rookie Ben Warren. The team also works closely with Seattle PD, often running into Andy's former flame Ryan Tanner.

At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

Set in Chicago, this medical drama deals with the personal and professional crises of the doctors in the emergency room at County General Hospital. From the exciting to the mundane, a day in the frantic hospital serves up many interesting dilemmas as well as heartrending choices for everyone on staff.

Annalise Keating (Oscar- and Tony-winning actress Viola Davis), a brilliant, charismatic and seductive professor of defense law, teaches a class called How to Get Away With Murder. Annalise, also a criminal defense attorney, selects a group of students -- the best and the brightest -- to assist with cases at her firm alongside her employees, the trustworthy and discreet Frank Delfino (Charlie Weber) and Bonnie Winterbottom ("Gilmore Girls" alum Liza Weil), an associate attorney. Mysteries arise that test everyone's limits and reveal dark truths.

Conrad Hawkins is one of Chastain Park Memorial Hospital's best doctors. Charming and arrogant, Conrad likes to take an unconventional approach whenever possible and believes it's his personal duty to shatter the romantic illusions of the first-year residents. Dr. Devon Pravesh is an innocent idealist who leans on his finely tuned moral compass, but with Conrad's help, he begins to realize that the practice of medicine is a business, like any other, with less-than-angelic patients and fallible doctors.

Shaun Murphy, a young autistic surgeon who has savant syndrome, relocates from a quiet country life to join the surgical unit at the prestigious San Jose St. Bonaventure Hospital -- a move strongly supported by his mentor, Dr. Aaron Glassman. Having survived a troubled childhood, Shaun is alone in the world and unable to personally connect with those around him, but he finds his niche using his extraordinary medical skill and intuition to save lives and challenge the skepticism of his colleagues.