An anonymous letter, containing details only the killer would know, offers clues to solving a murder.

Parents claim that their young daughter was attacked and killed by the family dogs.

A girl who is abducted and then released soon afterwards uses her knowledge of forensics to lead police to the kidnapper.

Insect evidence helps to solve the mystery of a woman found dead near a river bank.

The serial number on an artificial hip helps to solve a mystery.

Police find fragments of deleted computer files leading them to suspect a woman's suicide is really murder.

A seemingly model citizen turns out to be a serial killer.

The romantic involvement of two police officers with a prostitute complicates the investigation of her death.

A vehicle accident which leaves a young girl critically injured is deemed to be a hit-and-run; the girl's mother believes she can trace the driver and, using her own detective skills, goes on to gather evidence about the driver's identity.

A woman dies in a horseback-riding accident, but investigators find facts that make her husband a murder suspect.

A badly burned body is discovered after a murder-mystery theater performance.

The pregnant wife of a young, successful attorney is found dead from a shotgun wound to the head; detailed analysis suggests that it wasn't suicide.

A young woman goes missing without leaving many clues, but the advanced technology on offer makes it possible for cat hairs and insects to help build an image of the abductor.

Doctors cannot pinpoint the source of a businessman's illness.

A coroner finds telltale clues on the badly burned body of a murder victim, sending police in pursuit of a couple of killers.

A suspicious neighbor gives police a break in a cold case.

The similarities between an attack on a Maine State Trooper and the murder of a woman in New Jersey speed up the investigation into the killer's identity.

A medical examiner uses a "signature" clue to link a female prison guard's death to a murder 10 years earlier.

Investigators draw on medical science to solve baffling crimes.

A girl faces her dark secret a year after the passing of her father.

Two sets of scientists probe a woman's death.

Victims' rights activist John Walsh returns to weekly TV as host of a documentary-style investigation series. Walsh details stories of ongoing cases involving fugitives, with the intent of expanding searches outside the United States. Interviews with victims, loved ones and law enforcement accompany new leads in each hourlong episode, giving the public information to facilitate the capture of suspects. Walsh, a spokesman for the National Center for Missing & Exploited Children, hosted the series "America's Most Wanted" for 25 years, helping apprehend more than 1,200 criminals.

This newsmagazine investigates intriguing crime and justice cases that touch on all aspects of the human experience. Over its long run, the show has helped exonerate wrongly convicted people, driven the reopening -- and resolution -- of cold cases, and changed numerous lives. CBS News correspondents offer an in-depth look into each story, with the emphasis on solving the mystery at its heart. The program and its team have earned critical acclaim, including 20 Emmys and three Peabody Awards.

Think "Cold Case" meets "CSI" with a bit of "Rizzoli & Isles" mixed in, then make it real. That's the formula for this unscripted procedural drama that follows two veteran female investigators as they attempt to crack murder cases that have lingered for years without answers and closure. Kelly Siegler is an attorney and former Texas prosecutor who successfully tried 68 murder cases in her 21 years on the job, including 20 capital murder death penalty cases in which she secured the death penalty in 19 of those trials. She gets help from veteran detectives, who dig into small-town murder cases that have gone unsolved for years in the hope of getting justice for the victims and their loved ones.

"Dateline" has been a staple of the newsmagazine genre since premiering in 1992. Given how long it's been on the air, the show has an extensive archive of in-depth news stories and investigative journalism. This syndicated version offers viewers another chance to watch some of the show's previous content, serving up real-life mysteries and in-depth investigations from the show's 20-plus years on the air. Cases involving murders and missing people are frequent topics on the series that has won multiple Emmys in the news and documentary category.

Anchored by Lester Holt, "Dateline" is NBC's signature newsmagazine, bringing viewers storytelling at its best by putting the pieces together to present the full picture of real-life events. NBC News correspondents cover compelling stories and issues of the day, ranging from mystery and crime to in-depth investigations and breaking-news events.

Dr. Mark Sloan is chief of Internal Medicine at Community General Hospital -- and sometime consultant to the local police department. When he's drawn into a case, he combines sleuthing and medicine to solve the crime. That crime is usually one his detective son, Steve, is working on as a member of the local police department. Dr. Sloan's medical colleagues, including doctors Amanda Bentley, Jack Stewart and Jesse Travis, are also frequently drawn into his investigations.