This take on Sir Arthur Conan Doyle's classic character has Sherlock Holmes fleeing London for present-day Manhattan after a stint in rehab. He arrives to find that his father has assigned a sober companion to live with him -- Dr. Joan Watson, a former surgeon who gave up medicine three years earlier after she lost a patient. Her life now centers around helping addicts stay clean. However, Holmes has his own plan for keeping on the straight and narrow, throwing himself into his work as a police consultant in New York City. The two find that they make a good team and are soon cracking some of the NYPD's most-difficult cases.
In this contemporary version of Sir Arthur Conan Doyle's detective stories, Dr. John Watson is a war vet just home from Afghanistan. He meets the brilliant but eccentric Holmes when the latter, who serves as a consultant to Scotland Yard, advertises for a flatmate. Almost as soon as Watson moves into the Baker Street flat, they are embroiled in mysteries, and Sherlock's nemesis, Moriarty, appears to have a hand in the crimes.
Tom Selleck stars as Frank Reagan, the New York Police Commissioner, and patriarch of the Reagan clan, a multigenerational family of cops. Frank's oldest son is Danny, a seasoned detective and Iraqi War veteran who occasionally uses dubious tactics to solve cases. Daughter Erin, the lone female, is an assistant district attorney. Fresh out of Harvard Law, Jamie is the youngest member and "golden boy" of the family. Jamie gave up a lucrative future in law to continue the family's tradition in police work, and is asked to participate in a secretive investigation that even his father does not know about.
New York detective and single mom Harlee Santos must walk the thin line between loyalty and betrayal. She's forever dedicated to her team -- especially to her boss and mentor Lt. Matt Wozniak, a dirty cop who's always kept her family safe. But when ruthless FBI agent Robert Stahl catches her on the take, he leaves her no choice but to turn on her own. Though the mounting pressure on both sides is constant and influences her every move, Harlee stops at nothing to protect herself -- and those she loves.
Dr. Temperance Brennan, a forensic anthropologist who works at the Jeffersonian Institution and also writes books, has an impressive ability to read clues from victims' bones. Consequently, law enforcement calls her to assist with investigations when remains are so badly decomposed, burned or destroyed that standard identification methods are useless. Brennan is teamed with Special Agent Seeley Booth, a former Army sniper, who mistrusts science and scientists when it comes to solving crimes but who has developed respect for Brennan, both professionally and personally.
Filmed on location in New York, the drama showcases the sometimes-complex process of determining guilt or innocence, while lives hang in the balance. Often inspired by the latest headlines, the plots highlight legal, ethical or personal dilemmas to which people can relate.