Based off a podcast of the same name, "Up and Vanished" follows Payne Lindsey at the point where the podcast left off. With an investigation that leads to the arrest of two men who plead not guilty and are still awaiting trial in the disappearance of a beauty queen and high school teacher named Tara Grinstead. Combining stories with a cinematic storytelling technique Lindsey scrutinizes alibis and double check reports as the team stops at nothing on their search for the truth.