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When Becca Winstone's son, Michael, disappears while studying abroad, there is nothing that will stop her from getting him back. She begins her search in Rome, where Michael was last known to be, and tracks clues across Europe, seeking help from old friends and opening old wounds along the way. The kidnappers soon discover that between her special skills -- she was a lethal CIA operative before the death of her CIA agent husband a decade earlier -- and a mother's love they have picked a fight with the wrong woman.

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An obsessed man unable to accept the abduction of his young son spends years searching for him.
Jane Sadler is the overworked producer of a controversial show about law enforcement. Already spread thin between work and a separation from her husband, she's dealt a brutal blow when her young daughter goes missing in the middle of the night. The line between her personal life and the show blurs more than she ever thought possible as she wades through the devastating mystery of her daughter's disappearance. She discovers that everyone seems to have a secret, and there is no longer anyone she can truly trust.
Former CIA agent Reese (Jim Caviezel) -- now presumed dead -- and billionaire software genius Finch (Michael Emerson) join forces as a vigilante crime-fighting team. Using Finch's program, which employs pattern recognition to determine individuals who will soon be involved in violent crimes, they combine Reese's covert-operations training and Finch's money and cyberskills to stop crimes before they happen. Former Army Intelligence Support Activity operative Sameen Shaw joins the pair in their quest.
Brenda Johnson, an Atlanta police detective, moves to Los Angeles and heads up a squad that handles sensitive, high-profile homicides. Although she clashes with some colleagues, her skills as a CIA-trained interrogator prove invaluable in obtaining confessions.
Michael Westen is steamed -- or, more precisely, burned. His career as a spy ends when he gets a "burn notice," the covert equivalent of a pink slip. Stuck in his hometown of Miami, he intends to find out who did this to him and why, although that's not easy to do: With the burn notice attached to his name, he is cut off from his usual contacts and has to fly under the radar of the intelligence network lest he tip off his secret enemy. So it's a good thing he can rely on help from Fiona, his ex-girlfriend and IRA spy, and his friend Sam, also a former spy. Then there's Madeline, Michael's mother, a hypochondriac but probably not a spy.
The third time turns out to be the charm for criminal Neal Caffrey. He has been eluding FBI agent Peter Burke for years, a run that finally comes to an end with his capture. But after the resourceful prisoner escapes from a maximum-security facility, then is nabbed once again by Burke, Caffrey suggests a different end-game: In return for freedom, he'll help the Feds catch long-sought criminals. Though skeptical, Burke soon realizes that Caffrey's instincts and insight are a rare commodity. Caffrey's trusted friend and co-conspirator with ties to the criminal underworld, Mozzie, also becomes a useful source for Burke and the FBI.
Melinda Gordon is a young woman who can communicate with the earthbound spirits of people who have died -- and who seek her help. She uses it to relay significant messages and important information to the living, but sometimes the messages she receives are intense and confusing. As a result the spirits' survivors often question her ability. But when she helps both the souls who contact her and those who are still alive, she knows that her talent is more asset than liability.
The disappearance of former college acquaintance Chantal leads several 20-somethings to get entangled in the mystery of how she went missing. Leading the search party is Dory, a lifelong doormat who works as a rich housewife's assistant. Dory makes it her personal mission to find Chantal -- and she's bringing her friends into the investigation with her. Self-diagnosed narcissist Elliott, who puts his ego aside long enough to agree to help Dory, is particularly good at detective work. Bubbly actress Portia excels at chatting up suspects for information because of her desperate need to be in the spotlight. Sheltered-but-sweet doofus Drew has to grow a spine to help solve the mystery and save his deteriorating relationship with Dory. Dory's ex-boyfriend Julian seeks the truth, regardless of who it hurts, because of his background as a journalist.
Hosted by veteran journalist Alex Paen, "Missing" features missing person cases, involving both adults and children, from across North America in an effort to help solve the cases. The show works with law enforcement agencies from across the nation, including the FBI, and missing person organizations to provide viewers with vital facts about missing individuals and to increase public awareness of the cases. The show has helped authorities locate and recover hundreds of missing persons since it premiered in 2003.