Accomplished actors Dianne Wiest and James Brolin star as the heads of a large, happy family, in which each member is approaching different milestones. Their eldest daughter, Heather (Betsy Brandt) and her husband consider having another child as they get closer to an empty nest; middle child Matt (Thomas Sadoski) thinks he has found true love; and the youngest of the three siblings, Greg (Colin Hanks) is overwhelmed after having his first child with his wife. Various perspectives are employed as each family member's story unfolds.
Adam has been operating under the assumption that his three children are little angels, but when his wife decides to rejoin the workforce after being a stay-at-home mom for 13 years, and he starts taking on more of the parenting responsibilities, he's quickly disavowed of that notion. Kate, a preteen, is a master manipulator and excited to take advantage of her father's naivete; Teddy spends too much time with his hands down his pants; and Emme frets over school. After recovering from the initial shock -- and with the advice of equally stressed parents Marie and Lowell -- Adam is confident he can lay down the law and keep the house in order.
Doug Heffernan puts in a long day's work delivering parcels and comes home each night to his loving wife, Carrie; unfortunately, he also comes home to his wacko father-in-law, Arthur.
Mike Baxter is the quintessential man's man. Unfortunately, there isn't a lot of room for that at home where he lives with his three daughters and wife, Vanessa. The only other male in the house is his oldest daughter's young son, Boyd. Now, after being a stay-at-home mom for years, Vanessa goes back to work, forcing Mike to take on more parental responsibility than ever before. But his daughters aren't prepared for their old-fashioned, hotheaded patriarch to take over the house. When not at home, Mike is surrounded by men at his job at sporting-goods retailer Outdoor Man, which sells items like guns, jerky and camouflage recliners.
Doctor-turned-comedic actor Ken Jeong plays the titular character in this sitcom about a brilliant physician with a questionable bedside manner. Always trying his hardest to be a good doctor (despite being a little too honest) and the best husband and father he can be, Ken's real skill seems to lie in driving his family and co-workers crazy with his well-intentioned efforts. Luckily for everyone, when it comes to keeping everything sane, Ken's psychotherapist wife Allison is just what the doctor ordered.
In the Heck family, middle-age, middle-class, middle-America mom Frankie Heck (two-time Emmy winner Patricia Heaton) uses a sense of humor to try to steer her family through life's ups and downs as she tackles her career goals. Her unflappable husband, Mike (Neil Flynn), is a manager at the local quarry. Oldest son Axl is an obstinate young man; awkward daughter Sue cannot seem to find her niche -- despite much enthusiasm in her attempts -- and youngest son Brick is an unusual child whose best friend is his backpack.
In the 1980s, geeky Adam uses a video camera to document his family's crazy life. His mother, Beverly, is overprotective and lacks boundaries, while his dad has a hot temper and finds it difficult to parent without screaming. Rounding out the clan are Adam's terrifying sister, Erica; his older brother, Barry, who has middle-child syndrome; and the family's beloved grandfather, Al "Pops" Solomon. Pops is responsible for wild antics, including offering drinks to Barry and teaching Adam about the ways of love -- which create more chaos in an already high-strung family.
Maya DiMeo, a wife and mother, is fiercely protective of her husband, Jimmy, and their three children, Ray, Dylan, and J.J. -- who has a condition that leaves him with unique mobility and communication challenges. While Maya's mama bear instinct may be one of her most admirable qualities, it's not without its drawbacks and sometimes the injustices she sets out to make right end up being all in her head. Together, the family members work to make a new home for themselves and find the right person to come in and give J.J. a voice of his own.
Dr. Jason Bull is the charming and cocky founder of successful trial consulting firm Trial Analysis Corporation, where he and his team of experts employ psychology, human intuition and high-tech data to understand jurors, lawyers, witnesses and defendants, and construct effective narratives to help their clients win. Bull's team include his brother-in-law Benny, neurolinguistics expert Marissa, former detective Danny, hacker Cable, and Chunk, who helps perfect clients' appearances for trial. "Bull" is inspired by the early career of Dr. Phil McGraw, who also serves as executive producer.
Dre Johnson (Anthony Anderson) has it all: a great job, a beautiful wife, Rainbow (Tracee Ellis Ross), four kids and a big home in a classy neighborhood, but as a black man, he begins to question whether all his success has brought too much cultural assimilation for his family. With the help of his father (special guest star Laurence Fishburne), Dre begins to try to create a sense of ethnic identity for the members of his family that will allow them to honor their background while preparing them to embrace the future.