When Jane Doe is found naked in Times Square with her memory erased and her body covered in fresh tattoos, Agent Kurt Weller and his FBI team are instantly drawn to the case. Together, they discover each tattoo is a clue, making Jane's body a maze of mysteries that must be solved to uncover her true identity. But as Jane and Weller get closer to unveiling her past and discovering who set this riddle in motion, they find the quandary goes deeper than they ever imagined, involving people they thought they could trust.
The third time turns out to be the charm for criminal Neal Caffrey. He has been eluding FBI agent Peter Burke for years, a run that finally comes to an end with his capture. But after the resourceful prisoner escapes from a maximum-security facility, then is nabbed once again by Burke, Caffrey suggests a different end-game: In return for freedom, he'll help the Feds catch long-sought criminals. Though skeptical, Burke soon realizes that Caffrey's instincts and insight are a rare commodity. Caffrey's trusted friend and co-conspirator with ties to the criminal underworld, Mozzie, also becomes a useful source for Burke and the FBI.
New York detective and single mom Harlee Santos must walk the thin line between loyalty and betrayal. She's forever dedicated to her team -- especially to her boss and mentor Lt. Matt Wozniak, a dirty cop who's always kept her family safe. But when ruthless FBI agent Robert Stahl catches her on the take, he leaves her no choice but to turn on her own. Though the mounting pressure on both sides is constant and influences her every move, Harlee stops at nothing to protect herself -- and those she loves.
For decades, ex-government agent Raymond "Red" Reddington has been one of the globe's most wanted fugitives. But then he agreed to work with the FBI to catch his "blacklist" of mobsters, spies and international terrorists -- on the condition that he must work with profiler Elizabeth Keen. Red's true intentions -- choosing Liz, a woman with whom he seemingly has no connection -- are unclear. Does Liz have secrets of her own? Red promises to teach Liz to think like a criminal "to see the bigger picture," whether she wants to or not.
An elite squad of FBI profilers analyzes the country's most-twisted criminal minds, anticipating the perpetrators' next moves before they can strike again. Each member of the "mind hunter" team brings his or her expertise to pinpoint predators' motivations and identify emotional triggers to stop them. The core group includes an official profiler who is highly skilled at getting into the minds of criminals, a quirky genius, the former media liaison who manages to adeptly balance family life and the job, and a computer wizard.
A dedicated group of forensic investigators at the Las Vegas Crime Lab works to solve often-grisly crimes in Sin City. Heading up the graveyard shift (an appropriate term in this case) is supervisor D.B. Russell, a "Left Coast" Sherlock Holmes who devours crime novels. Members of Russell's team include Julie Finlay, Nick Stokes, Sara Sidle (the team's moral compass), Greg Sanders and Morgan Brody. The investigative team works closely with Capt. Jim Brass -- a seasoned detective who is a protector of CSI -- Dr. Al Robbins -- medical examiner -- and quirky lab technician David Hodges. Previous leaders of the group include Gil Grissom and Dr. Ray Langston.
Dr. Temperance Brennan, a forensic anthropologist who works at the Jeffersonian Institution and also writes books, has an impressive ability to read clues from victims' bones. Consequently, law enforcement calls her to assist with investigations when remains are so badly decomposed, burned or destroyed that standard identification methods are useless. Brennan is teamed with Special Agent Seeley Booth, a former Army sniper, who mistrusts science and scientists when it comes to solving crimes but who has developed respect for Brennan, both professionally and personally.
This take on Sir Arthur Conan Doyle's classic character has Sherlock Holmes fleeing London for present-day Manhattan after a stint in rehab. He arrives to find that his father has assigned a sober companion to live with him -- Dr. Joan Watson, a former surgeon who gave up medicine three years earlier after she lost a patient. Her life now centers around helping addicts stay clean. However, Holmes has his own plan for keeping on the straight and narrow, throwing himself into his work as a police consultant in New York City. The two find that they make a good team and are soon cracking some of the NYPD's most-difficult cases.